960210-99-5

960210-99-5 structure

Name: Plocabulin
Chemical Name: plocabulin
CAS Number: 960210-99-5
Molecular Formula: C₃₁H₄₅N₃O₇
Molecular Weight: 571.705
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2020-01-11 19:44:49
Modify Date: 2024-01-21 17:35:34
Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.

Name	plocabulin
Synonyms	plocabulin (1Z,4S,6Z)-1-[(N-{(2Z,4Z,6E,8S)-8-[(2S)-5-Methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methyl-2,4,6-nonatrienoyl}-3-methyl-L-valyl)amino]-1,6-octadien-4-yl carbamate 52Y8L60CR7 PM-060184 2,4,6-Nonatrienamide, N-[(1S)-1-[[[(1Z,4S,6Z)-4-[(aminocarbonyl)oxy]-1,6-octadien-1-yl]amino]carbonyl]-2,2-dimethylpropyl]-8-[(2S)-3,6-dihydro-5-methoxy-6-oxo-2H-pyran-2-yl]-6-methyl-, (2Z,4Z,6E,8S)-

Description	Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.
References	References 1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164. 2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616. 3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. 4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. View Related Products by Target Microtubule/Tubulin