Adenosine amine congener

Modify Date: 2024-01-08 08:52:22

Adenosine amine congener structure	Common Name	Adenosine amine congener
	CAS Number	96760-69-9	Molecular Weight	576.60400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₂N₈O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Adenosine amine congener

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].

Name	[3h]-adac
Synonym	More Synonyms

Description	Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A1 adenosine receptor[1][2]
In Vitro	Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways[1].
In Vivo	Adenosine amine congener (25-300 μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1]. Animal Model: Male Wistar rats (8-10 weeks old) treated with noise exposure[1] Dosage: 25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300 μg/kg/day Administration: Intraperitoneal injection; daily; for 5 days Result: Most effective in the first 24 hours after noise exposure at doses >50 μg/kg, and provided up to 21 dB protection (averaged across 8-28 kHz).
References	[1]. Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489. [2]. Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81.

Molecular Formula	C₂₈H₃₂N₈O₆
Molecular Weight	576.60400
Exact Mass	576.24400
PSA	209.77000
LogP	1.21720

Adenosine amine congener MSDS(Chinese)

(4-Aminophenyl)acetic acid structure

(4-Aminophenyl)...

CAS#:1197-55-3

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Adenosine amine congener Structure

Adenosine amine...

CAS#:96760-69-9

Literature: Jacobson; Kirk; Padgett; Daly Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1341 - 1346

Precursor 1
CAS#:1197-55-3 (4-Aminophenyl)...
DownStream 0

Adenosine amine congener hydrate

Adenosine Amine Congener

DC Chemicals Limited
China
Product Name: Adenosine Amine Congener
Price: $500.0/100mg $850.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥3170/10 mM * 1 mL in DMSO

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