ACETARSONE

Modify Date: 2026-07-01 09:49:09

ACETARSONE Structure
ACETARSONE structure
Common Name ACETARSONE
CAS Number 97-44-9 Molecular Weight 275.09000
Density N/A Boiling Point 72.17°C
Molecular Formula C8H10AsNO5 Melting Point 220.5°C
MSDS N/A Flash Point N/A

 Use of ACETARSONE


Acetarsol (Stovarsol) is a potent and orally active anti-infective agent. Acetarsol shows anti-parasite activity. Acetarsol has the potential for the research of proctitis[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name acetarsone
Synonym More Synonyms

 ACETARSONE Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Acetarsol (Stovarsol) is a potent and orally active anti-infective agent. Acetarsol shows anti-parasite activity. Acetarsol has the potential for the research of proctitis[1].
Related Catalog
In Vivo Acetarsol (20 mg/kg;p.o.;每天一次,持续 4 天) 在猪的毛囊炎中表现出抗感染活性[1]。 Animal Model: 2-month old piglets with Balantidium coli infected[1] Dosage: 20 mg/kg Administration: P.o.; once daily for 4 days Result: Showed 65% of piglets had clinically recovered, at the end of the treatment no diarrhoea was observed in any of the animals.
References

[1]. Argyriou K, et al. Acetarsol in the management of mesalazine-refractory ulcerative proctitis: a tertiary-level care experience. Eur J Gastroenterol Hepatol. 2019 Feb;31(2):183-186.  

[2]. V.S. Pandey, et al. Successful therapy of balantidiosis of pigs with acetarsol and oxytetracycline. Veterinary parasitology. 1977, 3(2):189-193.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Boiling Point 72.17°C
Melting Point 220.5°C
Molecular Formula C8H10AsNO5
Molecular Weight 275.09000
Exact Mass 274.97700
PSA 106.86000
Appearance of Characters solid
InChIKey ODFJOVXVLFUVNQ-UHFFFAOYSA-N
SMILES CC(=O)Nc1cc([As](=O)(O)O)ccc1O

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CF8400000
CHEMICAL NAME :
m-Arsanilic acid, N-acetyl-4-hydroxy-
CAS REGISTRY NUMBER :
97-44-9
BEILSTEIN REFERENCE NO. :
2941984
LAST UPDATED :
199703
DATA ITEMS CITED :
34
MOLECULAR FORMULA :
C8-H10-As-N-O5
MOLECULAR WEIGHT :
275.11
WISWESSER LINE NOTATION :
Q-AS-QO&R DQ CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
86 mg/kg/8D
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
89 mg/kg/9D
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Endocrine - other changes Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
155 mg/kg/2D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1576 mg/kg/2D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - urine volume decreased
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes T: Toxic;N: Dangerous for the environment;
Risk Phrases R23/25
Safety Phrases S28;S45;S60;S61
RIDADR UN 3465 6.1/PG 2
WGK Germany 3
RTECS CF8400000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2931900090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

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ACETARSONE Structure

ACETARSONE

CAS#:97-44-9

Learn More
Literature: Journal of the American Chemical Society, , vol. 43, p. 582,584 Journal of the American Chemical Society, , vol. 48, p. 1324

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ACETARSONE Structure

ACETARSONE

CAS#:97-44-9

Learn More
Literature: Journal of the American Chemical Society, , vol. 43, p. 582,584

~%

ACETARSONE Structure

ACETARSONE

CAS#:97-44-9

Learn More
Literature: Ann.Inst.Pasteur, vol. 37, p. 580 Chem. Zentralbl., , vol. 94, # III p. 1052

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  3

DownStream  4

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 ACETARSONEBioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
Name: qHTS for Inhibitors of TGF-b
Source: NCGC
Target: Smad3 [Homo sapiens]
External Id: SMAD3101
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

svc
Amassn
Oracid
amoebal
190f
MFCD00019936
amarsan
goyl
f190
Arsonic acid
4-hydroxy-3-acetylaminoarsanilic acid
EINECS 202-582-3
(3-Acetylamino-4-hydroxy-phenyl)-arsonsaeure
amasan
3-acetylamino-4-hydroxyphenylarsonic acid
3-Acetamino-4-hydroxy-phenylarsonsaeure
mexyl

 ACETARSONE | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of acetarsone?
A: Boiling point of acetarsone is 72.17°C.
Q: What is the SMILES notation of acetarsone?
A: SMILES notation of acetarsone is CC(=O)Nc1cc([As](=O)(O)O)ccc1O.
Q: What are the uses of acetarsone?
A: Main uses of acetarsone: Acetarsol (Stovarsol) is a potent and orally active anti-infective agent. Acetarsol shows anti-parasite activity. Acetarsol has the potential for the research of proctitis[1].
Q: What is the English name of acetarsone?
A: The English name of acetarsone is acetarsone.
Q: What is the physical appearance of acetarsone?
A: acetarsone appears as solid.
Q: What is the safety information for acetarsone?
A: Safety information for acetarsone: S28;S45;S60;S61.
Q: What is the InChIKey of acetarsone?
A: InChIKey of acetarsone is ODFJOVXVLFUVNQ-UHFFFAOYSA-N.
Q: What is the molecular weight of acetarsone?
A: Molecular weight of acetarsone is 275.09000.
Q: What is the polar surface area (PSA) of acetarsone?
A: Polar surface area (PSA) of acetarsone is 106.86000.
Q: What is the molecular formula of acetarsone?
A: Molecular formula of acetarsone is C8H10AsNO5.

 ACETARSONEfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

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