α-Hydroxytamoxifen

Modify Date: 2024-01-10 19:15:31

α-Hydroxytamoxifen Structure
α-Hydroxytamoxifen structure
Common Name α-Hydroxytamoxifen
CAS Number 97151-02-5 Molecular Weight 387.51400
Density 1.094g/cm3 Boiling Point 533.8ºC at 760 mmHg
Molecular Formula C26H29NO2 Melting Point 115-119ºC
MSDS N/A Flash Point 276.6ºC

 Use of α-Hydroxytamoxifen


α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts[1].

 Names

Name (E)-4-[4-[2-(dimethylamino)ethoxy]phenyl]-3,4-diphenylbut-3-en-2-ol
Synonym More Synonyms

 α-Hydroxytamoxifen Biological Activity

Description α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts[1].
Related Catalog
References

[1]. Phillips DH, et al. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes. Cancer Res. 1994 Nov 1;54(21):5518-22.

 Chemical & Physical Properties

Density 1.094g/cm3
Boiling Point 533.8ºC at 760 mmHg
Melting Point 115-119ºC
Molecular Formula C26H29NO2
Molecular Weight 387.51400
Flash Point 276.6ºC
Exact Mass 387.22000
PSA 32.70000
LogP 5.70170
Index of Refraction 1.595

 Safety Information

HS Code 2922509090

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

trans-(E)-4-[4-(2-dimethylamino-ethoxy)-phenyl]-3,4-diphenyl-but-3-en-2-ol
(E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-3-ol
Trans-Hydroxy-Tamoxifen
(E)-|A-Hydroxy Tamoxifen
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