Difenidol
Modify Date: 2025-08-21 09:18:07
Difenidol structure
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Common Name | Difenidol | ||
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| CAS Number | 972-02-1 | Molecular Weight | 309.44500 | |
| Density | 1.066 g/cm3 | Boiling Point | 473.3ºC at 760 mmHg | |
| Molecular Formula | C21H27NO | Melting Point | 105ºC | |
| MSDS | N/A | Flash Point | 233.5ºC | |
Use of DifenidolDiphenidol is an orally active antiemetic. Diphenidol reduces abnormal neuropathic pain and TNF-α overexpression in rats following chronic compression injury. Diphenidol also has local anaesthetic activity and inhibits sodium currents. Diphenidol can be used in studies of meniere′s disease, anti-vertigo, antiemetic and analgesia[1][2]. |
| Name | diphenidol |
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| Synonym | More Synonyms |
| Description | Diphenidol is an orally active antiemetic. Diphenidol reduces abnormal neuropathic pain and TNF-α overexpression in rats following chronic compression injury. Diphenidol also has local anaesthetic activity and inhibits sodium currents. Diphenidol can be used in studies of meniere′s disease, anti-vertigo, antiemetic and analgesia[1][2]. |
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| Related Catalog | |
| In Vitro | Diphenidol (0.1-100 µM) blocks Na+ currents with an IC50 of 0.77 µM and a Hill coefficient of 1.15 in N2A cells[1]. |
| In Vivo | Diphenidol (0.77 mg/rat; intrathecal injection; single) blocks motor function, proprioception, and nociception in rats[1]. Diphenidol (0.62, 3.09 mg/kg; i.p.; single daily for 7 days) effectively reverses or completely blocks CCI-evoked mechanical allodynia in rats[2]. Animal Model: Male SpragueeDawley rats (275-325 g)[1]. Dosage: 0.77 mg/rat (2.50 µmol/rat) Administration: Intrathecal injection; single. Result: Caused 100% of blockades in motor function, proprioception, and nociception with durations of action of about 51, 77, and 123 min, respectively. Animal Model: Male adult Sprague-Dawley rats (200-250 g; CCI rat model)[2]. Dosage: 0.62, 3.09 mg/kg (2, 10 µmol/kg) Administration: Intraperitoneal injection; single daily for 7 days. Result: Blocked the CCI-induced low mechanical withdrawal threshold at 1 h after administration. Reduced the level of TNF-α on day 7 and alleviated neuropathic tactile allodynia following CCI in rats. |
| Density | 1.066 g/cm3 |
|---|---|
| Boiling Point | 473.3ºC at 760 mmHg |
| Melting Point | 105ºC |
| Molecular Formula | C21H27NO |
| Molecular Weight | 309.44500 |
| Flash Point | 233.5ºC |
| Exact Mass | 309.20900 |
| PSA | 23.47000 |
| LogP | 4.12650 |
| Index of Refraction | 1.5614 (estimate) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2933399090 |
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~10%
Difenidol CAS#:972-02-1 |
| Literature: Schmidt, Andreas; Marchetti, Mauro; Eilbracht, Peter Tetrahedron, 2004 , vol. 60, # 50 p. 11487 - 11492 |
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~%
Difenidol CAS#:972-02-1 |
| Literature: Helvetica Chimica Acta, , vol. 24, p. 209 E, 220 E Journal of the American Chemical Society, , vol. 74, p. 4085 |
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~%
Difenidol CAS#:972-02-1 |
| Literature: Journal of Organometallic Chemistry, , vol. 332, p. 9 - 18 |
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~%
Difenidol CAS#:972-02-1 |
| Literature: GB683950 , ; |
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Difenidol |
| 1,1-diphenyl-4-piperidylbutanol |
| Vontrol |
| Nometic |
| 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol |
| DIPHENIDOL |
| defenidol |
| Difenidolo [DCIT] |
| Difenidolo |
| Cephadol |
| Difenidolum |
| Avomol |
| 1,1-diphenyl-4-piperidin-1-yl-butan-1-ol |