P-glycoprotein targeted nanoscale drug carriers

W Li, DA Samra, J Merzaban…

Index: Li, Wengang; Samra, Dina Abu; Merzaban, Jasmeen; Khashab, Niveen M. Journal of Nanoscience and Nanotechnology, 2013 , vol. 13, # 2 p. 1399 - 1402

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Citation Number: 8

Abstract

Multi-drug resistance (MDR) is a trend whereby tumor cells exposed to one cytotoxic agent develop cross-resistance to a range of structurally and functionally unrelated compounds. P- glycoprotein (P-gp) efflux pump is one of the mostly studied drug carrying processes that shuttle the drugs out of tumor cells. Thus, P-gp inhibitors have attracted a lot of attention as they can stop cancer drugs from being pumped out of target cells with the consumption of ...