Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides

ET Nadres, A Lazareva, O Daugulis

Index: Nadres, Enrico T.; Lazareva, Anna; Daugulis, Olafs Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 471 - 483

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Citation Number: 104

Abstract

The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-( dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron- poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and ...

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