Palladium??Catalyzed Direct Denitrogenative C??3??Arylation of 1H??Indoles with Arylhydrazines using Air as the Oxidant

Y Chen, S Guo, K Li, J Qu, H Yuan…

Index: Chen, Yongxin; Guo, Shuaibo; Li, Kangning; Qu, Jinpeng; Yuan, Hua; Hua, Qiuru; Chen, Baohua Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 711 - 715

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Citation Number: 32

Abstract

Abstract A novel palladium-catalyzed approach to direct C-3-arylation of 1H-indoles with arylhydrazines using air as the oxidant via C [BOND] N bond cleavage has been developed. Various substituents are tolerated in this system in moderate to good yields. This reaction could also be compatible with a larger scale. Thus, this strategy using arylhydrazines as arylating reagents provides a powerful method for constructing substituted 3-aryl-1H- ...

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