Tetrahedron

Direct synthesis of 3-arylindoles via annulation of aryl hydroxylamines with alkynes

AA Lamar, KM Nicholas

Index: Lamar, Angus A.; Nicholas, Kenneth M. Tetrahedron, 2009 , vol. 65, # 19 p. 3829 - 3833

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Citation Number: 27

Abstract

3-Arylindoles are produced in moderate to excellent yields from the reaction between aryl hydroxylamines and alkynes catalyzed by 10mol% iron (II) phthalocyanine [Fe (Pc)]. Terminal and internal alkynes afford 3-aryl substituted indoles exclusively. Electron-donating and-withdrawing groups are tolerated on the aryl hydroxylamine. A few bioactive indoles are synthesized as well as several new indoles using this one-step intermolecular annulation ...

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