Resolution of Racemic N??Benzyl α??Amino Acids by Liquid??Liquid Extraction: A Practical Method Using a Lipophilic Chiral Cobalt (III) Salen Complex and Mechanistic …

…, M Krupicka, I Tvaroska, C Gennari

Index: Dzygiel, Pawel; Reeve, Toby B.; Piarulli, Umberto; Krupicka, Martin; Tvaroska, Igor; Gennari, Cesare European Journal of Organic Chemistry, 2008 , # 7 p. 1253 - 1264

Full Text: HTML

Citation Number: 21

Abstract

Abstract The efficient resolution of racemic N-benzyl α-amino acids (N-Bn-AA) has been achieved by a liquid-liquid extraction process using the lipophilic chiral salen–cobalt (III) complex [Co III (3)(OAc)]. As a result of the resolution by extraction, one enantiomer (S) of the N-benzyl α-amino acid predominated in the aqueous phase, while the other enantiomer (R) was driven into the organic phase by complexation to cobalt. The complexed amino ...

Related Articles:

A facile synthesis of 1, 5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

[Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519]

The first highly enantioselective homogeneously catalyzed asymmetric reductive amination: synthesis of α-n-benzylamino acids

[Kadyrov, Renat; Riermeier, Thomas H.; Dingerdissen, Uwe; Tararov, Vitali; Boerner, Armin Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4067 - 4070]

Synthesis, CD Spectra, and Enzymatic Stability of β2??Oligoazapeptides Prepared from (S)??2??Hydrazino Carboxylic Acids Carrying the Side Chains of Val, Ala, and …

[Lelais, Gerald; Seebach, Dieter Helvetica Chimica Acta, 2003 , vol. 86, # 12 p. 4152 - 4168]

A facile synthesis of 1, 5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

[Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519]

A facile synthesis of 1, 5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

[Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519]

More Articles...