A facile synthesis of 1, 5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

TL Harris, RJ Worthington, C Melander

Index: Harris, Tyler L.; Worthington, Roberta J.; Melander, Christian Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4516 - 4519

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Citation Number: 17

Abstract

An efficient synthetic route to 1, 5-disubstituted 2-aminoimidazoles from readily available amino acids and aldehydes has been developed. A library of simple analogues was synthesized and several compounds were shown to exhibit notable antibiotic activity against a variety of bacterial strains including multi-drug resistant isolates.

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