Synthesis of macrocyclic dilactones by cyclization of sulfonium salts

T Nakamura, H Matsuyama, N Kamigata…

Index: Nakamura, Takako; Matsuyama, Haruo; Kamigata, Nobumasa; Iyoda, Masahiko Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3783 - 3789

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Citation Number: 20

Abstract

An efficient method for the formation of macrocyclic dilactones via cyclization of (wcarboxyalky1) diphenylsulfonium salts 3 containing an ester linkage under mild conditions is described. These sulfonium salta 3 were cyclized in the presence of cesium carbonate under high-dilution conditions to give 11-to 16-membered dilactones 4 in good yields. The cyclization of sulfonium salt 22 was successfully carried out for the synthesis of 11- ...

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