N-Boc-cis-4-Hydroxy-D-proline

Modify Date: 2024-01-02 14:18:42

N-Boc-cis-4-Hydroxy-D-proline Structure
N-Boc-cis-4-Hydroxy-D-proline structure
 Common Name N-Boc-cis-4-Hydroxy-D-proline
CAS Number 135042-12-5 Molecular Weight 231.246
Density 1.3±0.1 g/cm3 Boiling Point 390.9±42.0 °C at 760 mmHg
Molecular Formula C10H17NO5 Melting Point 145ºC
MSDS Chinese USA Flash Point 190.2±27.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of N-Boc-cis-4-Hydroxy-D-proline


N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth

 Names

Name Boc-Cis-4-Hydroxy-D-Proline
Synonym More Synonyms

 N-Boc-cis-4-Hydroxy-D-proline Biological Activity

Description N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 390.9±42.0 °C at 760 mmHg
Melting Point 145ºC
Molecular Formula C10H17NO5
Molecular Weight 231.246
Flash Point 190.2±27.9 °C
Exact Mass 231.110672
PSA 87.07000
LogP -0.71
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.531
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26
RIDADR NONH for all modes of transport
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
N-Boc-cis-4-Hydroxy-D-proline
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
(4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline
(2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid
MFCD02094407
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-
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(2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester
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N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
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Chemsrc provides N-Boc-cis-4-Hydroxy-D-proline(CAS#:135042-12-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of N-Boc-cis-4-Hydroxy-D-proline are included as well.>> amp version: N-Boc-cis-4-Hydroxy-D-proline

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