Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA

…, T Eidem, PM Dunman, M Abou-Gharbia

Index: Annadurai, Sivakumar; Martinez, Rogelio; Canney, Daniel J.; Eidem, Tess; Dunman, Paul M.; Abou-Gharbia, Magid Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7719 - 7725

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Citation Number: 20

Abstract

Privileged structure-based libraries have been shown to provide high affinity lead compounds for a variety of important biological targets. The present study describes the synthesis and screening of a 2-aminothiazole based compound library to determine their utility as antimicrobials, focusing on MRSA. Several of the compounds in this series demonstrated improved antimicrobial activity as compared to ceftriaxone (CTX), a β- ...