Comprehensive investigation of the energetics of pyrimidine nucleoside formation in a model prebiotic reaction

Y Sheng, HD Bean, I Mamajanov, NV Hud…

Index: Bean, Heather D.; Sheng, Yinghong; Collins, James P.; Anet, Frank A. L.; Leszczynski, Jerzy; Hud, Nicholas V. Journal of the American Chemical Society, 2007 , vol. 129, # 31 p. 9556 - 9557

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Citation Number: 21

Abstract

The problem of β-nucleoside formation under prebiotic conditions represents one of the most significant challenges to the “RNA world” hypothesis. The possibility exists that alternative bases may have come before the contemporary bases (ie, A, G, C, and U), including bases that more readily form nucleosides. We previously reported the first successful synthesis of a pyrimidine nucleoside from a free base and a nonactivated ...

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