Organic letters

Total synthesis of the hallucinogenic neoclerodane diterpenoid salvinorin A

…, Y Suka, T Hoshi, T Suzuki, H Hagiwara

Index: Nozawa, Masato; Suka, Yuhki; Hoshi, Takashi; Suzuki, Toshio; Hagiwara, Hisahiro Organic Letters, 2008 , vol. 10, # 7 p. 1365 - 1368

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Citation Number: 27

Abstract

Salvinorin A (1), a neoclerodane diterpenoid, isolated from the Mexican hallucinogenic plant Salvia divinorum, 1 is a selective κ-opioid receptor (KOR) agonist. 2 Its hallucinogenic activity is the most potent among any other known non-nitrogenous and nitrogenous compounds such as tetrahydrocannabinol (THC) or lysergic acid diethylamide (LSD), respectively. 1b,3 Since a different mechanism from LSD or mescaline is anticipated for its activity, salvinorin A (1) ...

Asymmetric synthesis of salvinorin A, a potent κ opioid receptor agonist