Total synthesis of 1233A

PM Wovkulich, K Shankaran, J Kiegiel…

Index: Wovkulich, P. M.; Shankaran, K.; Kiegiel, J.; Uskokovic, M. R. Journal of Organic Chemistry, 1993 , vol. 58, # 4 p. 832 - 839

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Citation Number: 77

Abstract

The total synthesis of the HMG-CoA synthase inhibitor 1233A (l), starting from either (Rbpulegone (6) or diketo ester 12, is described. The key transformations included the diastereoselective [2, 31 rearrangements of allylic ethers 9 and 19 to alcohols 10 and 1 lb, ...

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