Synthetic communications

Application of microwave irradiation techniques for the syntheses of cinnamic acids by Doebner condensation

AK Mitra, A De, N Karchaudhuri

Index: Mitra, Alok Kumar; De, Aparna; Karchaudhuri, Nilay Synthetic Communications, 1999 , vol. 29, # 4 p. 573 - 581

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Citation Number: 47

Abstract

Abstract The reaction rate of Doebner condensation to achieve cinnamic acids can be dramatically enhanced by irradiating the reaction mixture containing an aromatic aldehyde, malonic acid, pyridine and a trace of piperidine with a commercial microwave oven. Ten cinnamic acids were synthesized within 2-5 min in excellent yields.

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