Synthesis and evaluation of the pharmacological activity of rigid analogs of sympathomimetic catecholamines derived from bicyclo [2.2. 1] heptane

…, MC Breschi, A Lapucci, B Macchia…

Index: Balsamo, A.; Breschi, M. C.; Lapucci, A.; Macchia, B.; Macchia, F.; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 856 - 859

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Citation Number: 7

Abstract

Zstituto di Chimica Farmaceutica, Zstituto Policattedra di Discipline Biologiche, and Istituto di Chimica Organica, Facoltd di Farmacia, Uniuersitd di Pisa, 56100 Pisa, Italy. Received March 21, 1988 endo-3-Amino-exo-2-(3, 4-dihydroxyphenyl)-2-hydroxybicyclo [2.2. l] hep~ e (4a) and its N-isopropyl derivative (4b) were synthesized and assayed for their adrenergic activity on various isolated preparations. Compounds 4a and 4b, tested up to a dose of la- ...