Nature Cell Biology 2017-06-29

Lgr5 joins the club of gastric stem cell markers in the corpus

Toby J. Phesse, Owen J. Sansom

Index: 10.1038/ncb3567

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Abstract

Several markers of gastric stem cells have been identified in recent years. Now a study demonstrates that Lgr5 marks a population of reserve stem cells located at the base of the corpus glands of the gastric epithelium, and that these cells can also act as a cell-of-origin for gastric tumorigenesis.

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