Synthesis and Platelet Aggregation Inhibitory Activity of Diphenylazole Derivatives. I. Thiazole and Imidazole Derivatives

…, K YOSHINO, K YOKOTA, G TSUKAMOTO

Index: Seko; Yoshino; Yokota; Tsukamoto Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 651 - 657

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Citation Number: 3

Abstract

Diphenylimidazole and diphenylthiazole derivatives were synthesized and tested as inhibitors of platelet aggregation in in vitro experiments with the rabbit. Diphenylthiazole derivatives (10) were more potent than diphenylimidazole derivatives (4) in inhibiting arachidonic acid-induced platelet aggregation of rabbit platelet-rich plasma. Two diphenylimidazole and eight diphenylthiazole derivatives were evaluated for ex vivo ...