Potential antidepressants: 2-(Aminoalkoxy) biphenyls and some related ω-substituted 2-alkoxybiphenyls

I Červená, J Holubek, E Svátek, J Metyš…

Index: Cervena, Irena; Holubek, Jiri; Svatek, Emil; Metys, Jan; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 7 p. 1966 - 1978

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Citation Number: 4

Abstract

Abstract Reactions of 2-hydroxybiphenyl with α, ω-dibromoalkanes gave the 2- (bromoalkoxy) biphenyls IIIa-IIId. The 2-(dimethylaminoalkoxy) biphenyls VIa and VIb were transformed via carbamates VIIa and VIIb to the secondary amines Va and Vb. Their homologues Vc and Vd were obtained from the bromo compounds IIIc and IIId by treatment with methylamine. Bromo compounds IIIa and IIIb were reacted with 1-methylpiperazine, 2 ...