Synthesis

A Practical Synthesis of 1, 4-Diiodo-2, 5-bis (chloromethyl) benzene and 1, 4-Diiodo-2, 5-bis (bromomethyl) benzene

G Gaefke, V Enkelmann, S Höger

Index: Gaefke, Gerald; Enkelmann, Volker; Hoeger, Sigurd Synthesis, 2006 , # 17 p. 2971 - 2973

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Citation Number: 4

Abstract

In order to avoid any partial halogen exchange during the radical side chain halogenation, we decided to use 1,4-bis(hydroxymethyl)benzene (3) as the starting material for our synthesis. In this case, the side-chain carbon is already functionalized and should be transformable into the desired benzyl halides without problems. The hydroxy functions of 3 were protected as a diacetate and subsequently iodinated under acidic conditions using iodine/iodic acid. [12] ...

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