Synthesis and inhibitory activity on carbonic anhydrase of some new sulpiride analogs studied by means of a new method
…, F Botre, G Jommi, R Signorini
Index: Botre, Claudio; Botre, Francesco; Jommi, Giancarlo; Signorini, Roberto Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1814 - 1820
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Citation Number: 5
Abstract
The pharmacological activity of several new sulpiride analogues was studied by means of a new approach, based on a potentiometric technique with a pC0, sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions. This procedure gives results stated as percent of inhibition of enzymatic activity (IP, inhibitory power). To prove the reliability of the proposed approach and to study structure-activity relationships, several ...
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