Efficient synthesis of 2-ethoxycarbonyl indoles

…, H Jayadevappa, KM Mahadevan…

Index: Sudhakara; Jayadevappa; Mahadevan; Hulikal, Vijaykumar Synthetic Communications, 2009 , vol. 39, # 14 p. 2506 - 2515

Full Text: HTML

Citation Number: 21

Abstract

Abstract An efficient one-pot procedure for the synthesis of 2-ethoxycarbonyl indoles from commercially available materials has been developed. The one-step procedure involves in situ formation of the hydrazones from phenylhydrazine hydrochloride and ethyl pyruvate in the presence of bismuth nitrate followed by Fischer cyclization in polyphosphoric acid and ethanol. This method is efficient and simple.

Related Articles:

Gold (I)-catalyzed rearrangement of alkynylaziridine indoles for the synthesis of spiro-tetrahydro-β-carbolines

[Yang, Yan-Fang; Li, Lian-Hua; He, Yu-Tao; Luo, Jian-Yi; Liang, Yong-Min Tetrahedron, 2014 , vol. 70, # 3 p. 702 - 707]

Synthesis of Indoles through Highly Efficient Cascade Reactions of Sulfur Ylides and N??(ortho??Chloromethyl) aryl Amides

[Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140]

Synthesis of Indoles through Highly Efficient Cascade Reactions of Sulfur Ylides and N??(ortho??Chloromethyl) aryl Amides

[Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140]

Synthesis and biological evaluation of new 5-benzylated 4-oxo-3, 4-dihydro-5H-pyridazino [4, 5-b] indoles as PI3Kα inhibitors

[European Journal of Medicinal Chemistry, , vol. 57, p. 225 - 233]

Gold (I)-catalyzed rearrangement of alkynylaziridine indoles for the synthesis of spiro-tetrahydro-β-carbolines

[Tetrahedron, , vol. 70, # 3 p. 702 - 707]

More Articles...