Synlett

The room-temperature palladium-catalyzed cyanation of aryl bromides and iodides with tri-t-butylphosphine as ligand

J Ramnauth, N Bhardwaj, P Renton, S Rakhit…

Index: Ramnauth, Jailall; Bhardwaj, Namrta; Renton, Paul; Rakhit, Suman; Maddaford, Shawn P. Synlett, 2003 , # 14 p. 2237 - 2239

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Citation Number: 24

Abstract

Abstract The palladium-catalyzed cyanation of aryl bromides and iodides to the corresponding nitriles occurs at room temperature when tri-t-butylphosphine is used as ligand, Zn (CN) 2 as the cyanide source and Zn dust as a co-catalyst in DMF as solvent. A variety of aromatic halides, including electron-withdrawing and electron-donating, can be efficiently cyanated under these conditions. The reactions are completed in less than 1 ...

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