Synthesis and biological relationships of 3′, 6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents

…, KH Lee, Z Xiao, KF Bastow, T Yamori, SC Kuo

Index: Lai, Ya-Yun; Huang, Li-Jiau; Lee, Kuo-Hsiung; Xiao, Zhiyan; Bastow, Kenneth F.; Yamori, Takao; Kuo, Sheng-Chu Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 265 - 275

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Citation Number: 58

Abstract

As part of a continuing search for potential anticancer drug candidates in the 2-phenyl-4- quinolone series, 3′, 6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives and their salts were synthesized and evaluated. Preliminary screening showed that carboxylic acid analogs containing a m-fluoro substituted 2-phenyl group displayed the highest in vitro anticancer activity. Activity decreased significantly if a chlorine or methoxy group replaced ...