Analogs of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage

…, M Jarman, CS Leung, MG Rowlands…

Index: Foster; Jarman; Leung; Rowlands; Taylor Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 50 - 54

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Citation Number: 69

Abstract

In our probing of the structural features responsible for the inhibitory activity of aminoglutethimide [l, 344-aminophenyl)-3-ethylpiperidine-2, 6-dione] toward the cholesterol side-chain cleavage enzyme system desmolase and the estrogen-forming system aromatase, targets in the action of 1 against hormone-dependent mammary tumors, analogues in several categories have been synthesized and evaluated. Of the known ...