The intercalation of 6-chloro-2-substituted-9-[[3-(dimethylamino) propyl] amino] acridines with DNA

…, AL Baumstark, WD Wilson, DW Boykin

Index: Kitchen, S. E.; Wang, Yueh-Hwa; Baumstark, A. L.; Wilson, W. D.; Boykin, D. W. Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 940 - 944

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Citation Number: 7

Abstract

A series of 6-chloro-2-substituted-9-[[3-(dimethylamino) propyl] amino] acridines has been prepared. The binding affinities and the unwinding angles for the acridine derivatives, relative to ethidium, were determined from viscometric titrations with ccs-DNA. The binding affinities were the same, within experimental error, ca. 2.0 x 10”. Similarly, with the exception of 11, the unwinding angles were close to 17”. For 11 the unwinding angle (12O) was ...