Phenazine antibiotic inspired discovery of potent bromophenazine antibacterial agents against Staphylococcus aureus and Staphylococcus epidermidis

…, BQ Duong, JR Rocca, S Jin, RW Huigens III

Index: Borrero, Nicholas V.; Bai, Fang; Perez, Cristian; Duong, Benjamin Q.; Rocca, James R.; Jin, Shouguang; Huigens Iii, Robert W. Organic and Biomolecular Chemistry, 2014 , vol. 12, # 6 p. 881 - 886

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Citation Number: 16

Abstract

Nearly all clinically used antibiotics have been (1) discovered from microorganisms (2) using phenotype screens to identify inhibitors of bacterial growth. The effectiveness of these antibiotics is attributed to their endogenous roles as bacterial warfare agents against competing microorganisms. Unfortunately, every class of clinically used antibiotic has been met with drug resistant bacteria. In fact, the emergence of resistant bacterial infections ...