Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity

…, K Ruff, A Wrisch, S Grissmer, W Hänsel

Index: Wulff, Heike; Rauer, Heiko; Duering, Tim; Hanselmann, Christine; Ruff, Katharina; Wrisch, Anja; Grissmer, Stephan; Haensel, Wolfram Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4542 - 4549

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Citation Number: 79

Abstract

A series of psoralens and structurally related 5, 7-disubstituted coumarins was synthesized and investigated for their K+ channel blocking activity as well as for their phototoxicity to Artemia salina and their ability to generate singlet oxygen and to photomodify DNA. After screening the compounds on Ranvier nodes of the toad Xenopus laevis, the affinities of the most promising compounds, which proved to be psoralens bearing alkoxy substituents in ...