Tetrahedron

Controlled monohalogenation of phosphonates: A new route to pure α-monohalogenated diethyl benzylphosphonates

B Iorga, F Eymery, P Savignac

Index: Iorga, Bogdan; Eymery, Frederic; Savignac, Philippe Tetrahedron, 1999 , vol. 55, # 9 p. 2671 - 2686

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Citation Number: 49

Abstract

Starting from diethyl benzylphosphonates, a wide variety of diethyl α-monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCl followed by halogenation with an electrophilic halogenating reagent.

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