Convenient synthesis of oligodeoxyribonucleotides bearing arabinofuranosyl pyrimidine derivatives and its duplex formation with complementary DNA

…, K Nakajima, K Tatsui, C Izumi, M Kuwahara…

Index: Ozaki, Hiroaki; Nakajima, Kiyohiro; Tatsui, Kaoru; Izumi, Chieko; Kuwahara, Masayasu; Sawai, Hiroaki Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2441 - 2443

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Citation Number: 11

Abstract

The oligodeoxyribonucleotides bearing 2, 2′-anhydro-β-d-arabinofuranosyluracil derivatives were synthesized and the modified residue was converted to β-d- arabinofuranosyluracil derivatives or β-d-arabinofuranosylisocytosine derivatives by post- synthetic modification method. The melting profiles of their ODNs with complementary DNA were studied.