Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

JC Sutton, SA Bolton, ME Davis, KS Hartl…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2233 - 2239

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Citation Number: 54

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... difficulties when applied in a library format than the guanidine functionality present in 1. Therefore, solid-phase methods were developed to rapidly assess the SAR associated with the N1 position of compound 3. In this letter we report ...

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