Discovery of potent 3, 5-diphenyl-1, 2, 4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3

Z Li, W Chen, JJ Hale, CL Lynch, SG Mills…

Index: Journal of Medicinal Chemistry, , vol. 48, # 20 p. 6169 - 6173

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Citation Number: 97

Abstract

... Journal of Medicinal ... Departments of Medicinal Chemistry and Immunology & Rheumatology Research, Merck Research Laboratories, Rahway, New Jersey 07065, and ... conjugate addition of 4-(bromo)phenylboronic acid to cyclopentenone; 14 analogous chemistry was used to ...

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