Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids

MF Boehm, L Zhang, BA Badea, SK White…

Index: Boehm; Zhang; Badea; White; Mais; Berger; Suto; Goldman; Heyman Journal of Medicinal Chemistry, 1994 , vol. 37, # 18 p. 2930 - 2941

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Citation Number: 350

Abstract

Retinoids play important roles in a variety of biological processes including mediation of cell growth and differentiation. The ability of retinoids to modulate proliferation and differentiation of both normal and malignant cells in vivo and in vitro has significant implications for the treatment of dermatological diseases, such as psoriasis,'and cancer including chemotherapeutic and chemopreventative application^.^^^ Accordingly, the naturally ...

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