Bexarotene

Modify Date: 2025-08-21 14:37:35

Bexarotene structure	Common Name	Bexarotene
	CAS Number	153559-49-0	Molecular Weight	348.478
	Density	1.0±0.1 g/cm3	Boiling Point	489.7±44.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₂₈O₂	Melting Point	230-231ºC
	MSDS	Chinese USA	Flash Point	229.5±23.1 °C

Use of Bexarotene

Bexarotene is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma.

Name	bexarotene
Synonym	More Synonyms

Description	Bexarotene is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR Research Areas >> Cancer
References	[1]. Vakeva L, Ranki A, Hahtola S.Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland.Acta Derm Venereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359. [2]. Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P.Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphoma of the α/β Type with Bexarotene.Case Rep Dermatol. 2012 Jan;4(1):56-60. [3]. Orendas P, Kubatka P, Kajo K, Stollarova N, Kassayova M, Bojkova B, Pec M, Nosal V, Kiskova T, Zihlavnikova K, Karsnakova R.Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis.Neoplasma. 2012;59(4):469-74. [4]. Cras A, Politis B, Balitrand N, Darsin-Bettinger D, Boelle PY, Cassinat B, Toubert ME, Chomienne C.Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer.Clin Cancer Res. 2012 Jan 15;18(2):442-53. [5]. Gui Y, et al. Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1. J Pain. 2019 Jan 17. pii: S1526-5900(18)30607-2.

Description

Bexarotene is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma.

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

Research Areas >> Cancer

References

[1]. Vakeva L, Ranki A, Hahtola S.Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland.Acta Derm Venereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359.

[2]. Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P.Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphoma of the α/β Type with Bexarotene.Case Rep Dermatol. 2012 Jan;4(1):56-60.

[3]. Orendas P, Kubatka P, Kajo K, Stollarova N, Kassayova M, Bojkova B, Pec M, Nosal V, Kiskova T, Zihlavnikova K, Karsnakova R.Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis.Neoplasma. 2012;59(4):469-74.

[4]. Cras A, Politis B, Balitrand N, Darsin-Bettinger D, Boelle PY, Cassinat B, Toubert ME, Chomienne C.Bexarotene via CBP/p300 induces suppression of NF-κB-dependent cell growth and invasion in thyroid cancer.Clin Cancer Res. 2012 Jan 15;18(2):442-53.

[5]. Gui Y, et al. Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1. J Pain. 2019 Jan 17. pii: S1526-5900(18)30607-2.

Density	1.0±0.1 g/cm3
Boiling Point	489.7±44.0 °C at 760 mmHg
Melting Point	230-231ºC
Molecular Formula	C₂₄H₂₈O₂
Molecular Weight	348.478
Flash Point	229.5±23.1 °C
Exact Mass	348.208923
PSA	37.30000
LogP	8.55
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.556

Bexarotene MSDS(Chinese)

Hazard Codes	Xn
RIDADR	NONH for all modes of transport

Precursor 10
CAS#:153559-48-9 methyl 4-[1-(3,... CAS#:6683-48-3 1,1,4,4,6-PENTA... CAS#:153559-45-6 Methyl 4-[(5,6,... CAS#:110-03-2 2,5-Dimethyl-2,...
CAS#:1346970-00-0 bexarotene ethy... CAS#:6223-78-5 2,5-Dichloro-2,... CAS#:119999-22-3 6-BROMO-1,1,4,4... CAS#:29020-85-7 2(1H)-Naphthale...
CAS#:108-88-3 Toluene CAS#:167958-79-4 1,1,4,4,6-penta...
DownStream 0

Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma.

J. Invest. Dermatol. 135 , 2102-8, (2015)

Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of...

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.

Neurobiol. Dis. 82 , 132-40, (2015)

We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ level...

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.

J. Clin. Invest. 125(2) , 809-23, (2015)

Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogene...

Targretin

Bexarotene

4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid

LG 69

4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthalenyl)vinyl]benzoic acid

Lg 1069

4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid

Targretyn

Bexaroten

Targret

Benzoic acid, 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-

4-[1-(3,5,5,8,8-Pentamethyl-2-5,8-dihydronaphthyl)vinyl]benzoic acid

4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid

LGD1069

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Bexarotene

Use of Bexarotene

Names

Bexarotene Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Articles18

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.