An improved synthesis of antiulcerative drug: tenatoprazole

S Sripathi, RR Bojja, VR Karnati, VP Raju…

Index: Sripathi, Somaiah; Bojja, Ramachandra Reddy; Karnati, Venugopal Reddy; Prasada Raju; Khunt, Mayur D. Organic Process Research and Development, 2009 , vol. 13, # 4 p. 804 - 806

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Citation Number: 12

Abstract

An efficient, cost-effective and multikilogram-scale process for the synthesis of tenatoprazole 1, an antiulcerative drug, is described. The key steps in this synthesis involve the coupling of 2-mercapto-5-methoxyimidazo [4, 5-b] pyridine 2 with 2-chloromethyl-4-methoxy-3, 5- dimethyl pyridine hydrochloride 3 to yield 4 and its subsequent oxidation with m-CPBA to produce sulfoxide 1. The process has been scaled up for the multikilogram-scale of ...