Tenatoprazole

Modify Date: 2025-08-21 06:39:36

Tenatoprazole Structure
Tenatoprazole structure
 Common Name Tenatoprazole
CAS Number 113712-98-4 Molecular Weight 346.40
Density 1.4±0.1 g/cm3 Boiling Point 591.5±60.0 °C at 760 mmHg
Molecular Formula C16H18N4O3S Melting Point 178-180°C
MSDS Chinese USA Flash Point 311.5±32.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Tenatoprazole


Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV[1][2][3].

 Names

Name Tenatoprazole
Synonym More Synonyms

 Tenatoprazole Biological Activity

Description Tenatoprazole (TU-199) is an orally active imidazopyridine-based proton pump inhibitor with a prolonged plasma half-life. Tenatoprazole inhibits hog gastric H+/K+-ATPase activity with an IC50 of 6.2 μM. Tenatoprazole blocks the interaction of ubiquitin with the ESCRT-1 factor Tsg101, inhibits production of several enveloped viruses, including EBV[1][2][3].
Related Catalog
In Vitro Tenatoprazole (TU-199) (0.1, 0.2, 0.4 mg/kg; oral; single; Heidenhain-pouch dogs) dose-dependently suppresses gastric acid secretion stimulated by histamine infusion[4].
References

[1]. Thomson AB, et al. Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three-way crossover study. Aliment Pharmacol Ther. 2006;23(8):1179-1187.

[2]. Uchiyama K, et al. Effects of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion and gastroduodenal ulcers in rats. Methods Find Exp Clin Pharmacol. 1999;21(2):115-122.

[3]. Mannemuddhu SS, et al. Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency. J Virol. 2021;95(13):e0246620.

[4]. Uchiyama K, et al. The long-lasting effect of TU-199, a novel H+, K(+)-ATPase inhibitor, on gastric acid secretion in dogs. J Pharm Pharmacol. 1999;51(4):457-464.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 591.5±60.0 °C at 760 mmHg
Melting Point 178-180°C
Molecular Formula C16H18N4O3S
Molecular Weight 346.40
Flash Point 311.5±32.9 °C
Exact Mass 346.109955
PSA 109.20000
LogP 1.36
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.674
Storage condition −20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
Hazard Codes Xn: Harmful;
Risk Phrases R22
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine
(±)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-imidazo[4,5-b]pyridine
1H-Imidazo[4,5-b]pyridine, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-
5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-3H-imidazo[4,5-b]pyridine
tenatoprazole/tu-199
5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridin
Tenatoprazole
5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine
tenatoprazole monosodium
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Chemsrc provides Tenatoprazole(CAS#:113712-98-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tenatoprazole are included as well.>> amp version: Tenatoprazole

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