Rh (I)-catalyzed arylation of heterocycles via CH bond activation: expanded scope through mechanistic insight

…, AM Berman, RG Bergman, JA Ellman

Index: Lewis, Jared C.; Berman, Ashley M.; Bergman, Robert G.; Ellman, Jonathan A. Journal of the American Chemical Society, 2008 , vol. 130, # 8 p. 2493 - 2500

Full Text: HTML

Citation Number: 191

Abstract

A practical, functional group tolerant method for the Rh-catalyzed direct arylation of a variety of pharmaceutically important azoles with aryl bromides is described. Many of the successful azole and aryl bromide coupling partners are not compatible with methods for the direct arylation of heterocycles using Pd (0) or Cu (I) catalysts. The readily prepared, low molecular weight ligand, Z-1-tert-butyl-2, 3, 6, 7-tetrahydrophosphepine, which coordinates to Rh in ...

Related Articles:

Synthesis of 2-substituted benzimidazoles catalyzed by FeCl3/Al2O3 under ultrasonic irradiation

[Chen, Guo-Feng; Dong, Xiao-Yun; Meng, Fan-Zhu; Chen, Bao-Hua; Li, Ji-Tai; Wang, Shu-Xiang; Bai, Guo-Yi Letters in Organic Chemistry, 2011 , vol. 8, # 7 p. 464 - 469]

Palladium-catalyzed N-heteroannulation of N-allyl-or N-benzyl-2-nitrobenzenamines: synthesis of 2-substituted benzimidazoles

[Hubbard, Jeremiah W.; Piegols, Adam M.; Soederberg, Bjoern C.G. Tetrahedron, 2007 , vol. 63, # 30 p. 7077 - 7085]

Synthesis of benzimidazoles by Cu 2 O-catalyzed cascade reactions between o-haloaniline and amidine hydrochlorides

[Qu, Yanyang; Pan, Lei; Wu, Zhiqing; Zhou, Xiangge Tetrahedron, 2013 , vol. 69, # 6 p. 1717 - 1719]

One??pot synthesis of benzimidazoles from o??nitroanilines under microwaves via a reductive cyclization

[Surpur, Mandar P.; Singh, Pankajkumar R.; Patil, Sachin B.; Samant, Shriniwas D. Synthetic Communications, 2007 , vol. 37, # 8 p. 1375 - 1379]

Direct Imidation to Construct 1H??Benzo [d] imidazole through PdII??Catalyzed C H Activation Promoted by Thiourea

[Xiao, Qing; Wang, Wen-Hua; Liu, Gang; Meng, Fan-Ke; Chen, Jia-Hua; Yang, Zhen; Shi, Zhang-Jie Chemistry - A European Journal, 2009 , vol. 15, # 30 p. 7292 - 7296]

More Articles...