Tetrahedron

Synthesis of benzimidazoles by Cu 2 O-catalyzed cascade reactions between o-haloaniline and amidine hydrochlorides

Y Qu, L Pan, Z Wu, X Zhou

Index: Qu, Yanyang; Pan, Lei; Wu, Zhiqing; Zhou, Xiangge Tetrahedron, 2013 , vol. 69, # 6 p. 1717 - 1719

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Citation Number: 16

Abstract

An efficient Cu2O-catalyzed method for the synthesis of benzimidazole derivatives from amidine hydrochlorides and o-haloaniline has been developed. The cascade C–N coupling and intramolecular transamination reaction provided benzimidazole derivatives in high yields up to 90%.

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