Synthesis

An Efficient Hemisynthesis of 20-and 21-[¹³C]-Labeled Cortexolone: A Model for the Study of Skin Sensitization to Corticosteroids

E Claudel, C Arbez-Gindre, V Berl, JP Lepoittevin

Index: Claudel, Emilie; Arbez-Gindre, Cecile; Berl, Valerie; Lepoittevin, Jean-Pierre Synthesis, 2009 , # 20 p. 3391 - 3398

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Citation Number: 2

Abstract

Abstract A method is described for the synthesis of isotopomers of cortexolone from the commercially available andros-4-ene-3, 17-dione. The strategy is based on the use of K ¹³ CN for labeling at position 20 and of ¹³ CH 3 MgI, generated in situ, for labeling at position 21. Because of the early introduction of the [¹³ C] labeling, our efforts aimed at reproducible experimental procedures giving high yields with respect to the isotope containing ...

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