Self-Immolative Phthalate Esters Sensitive to Hydrogen Peroxide and Light

KM Mahoney, PP Goswami, A Syed…

Index: Mahoney, Kaitlyn M.; Goswami, Pratik P.; Winter, Arthur H. Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 702 - 705

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Abstract

Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7- hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.

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