Phthalic acid

Modify Date: 2024-01-01 17:28:43

Phthalic acid structure	Common Name	Phthalic acid
	CAS Number	88-99-3	Molecular Weight	166.131
	Density	1.5±0.1 g/cm3	Boiling Point	378.3±25.0 °C at 760 mmHg
	Molecular Formula	C₈H₆O₄	Melting Point	210-211 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	196.7±19.7 °C
	Symbol	GHS07	Signal Word	Warning

Use of Phthalic acid

Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].

Name	phthalic acid
Synonym	More Synonyms

Description	Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	IC50: metabolite of PAEs[1]
References	[1]. Du Yeon Bang, et al.Toxicological Characterization of Phthalic Acid. Toxicol Res 2011;27:191−203

Density	1.5±0.1 g/cm3
Boiling Point	378.3±25.0 °C at 760 mmHg
Melting Point	210-211 °C (dec.)(lit.)
Molecular Formula	C₈H₆O₄
Molecular Weight	166.131
Flash Point	196.7±19.7 °C
Exact Mass	166.026611
PSA	74.60000
LogP	0.81
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.618
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	7 g/L (25 ºC)

Phthalic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH9625000

CHEMICAL NAME :: Phthalic acid

CAS REGISTRY NUMBER :: 88-99-3

BEILSTEIN REFERENCE NO. :: 0608199

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H6-O4

MOLECULAR WEIGHT :: 166.14

WISWESSER LINE NOTATION :: QVR BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(8),12,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,711,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 49,471,1942 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 102 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 32(8),12,1967 *** REVIEWS *** TOXICOLOGY REVIEW BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 59185 No. of Facilities: 106 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 2321 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 59185 No. of Facilities: 1480 (estimated) No. of Industries: 22 No. of Occupations: 27 No. of Employees: 19693 (estimated) No. of Female Employees: 2861 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	TH9625000
HS Code	2917399090

Precursor 10
CAS#:95-47-6 o-xylene CAS#:643-79-8 o-Phthalaldehyde CAS#:201230-82-2 carbon monoxide CAS#:2042-37-7 2-Bromobenzonitrile
CAS#:5779-72-6 2,4,5-trimethyl... CAS#:88-67-5 2-Iodobenzoic acid CAS#:83-33-0 1-Indanone CAS#:67-56-1 Methanol
CAS#:583-53-9 1,2-Dibromobenzene CAS#:612-40-8 Benzoic acid,2-...
DownStream 10
CAS#:3130-75-4 4-(1,3-dioxo-1,... CAS#:57319-65-0 6-Amino-1,3-dih... CAS#:5383-82-4 Benzoic acid,4-... CAS#:40101-31-3 Phthalimide, N-...
CAS#:5434-20-8 3-Aminophthalic acid CAS#:3339-73-9 3-PHTHALIMIDOPR... CAS#:5434-21-9 4-Aminophthalic acid CAS#:56-55-3 Benz(a)anthracene
CAS#:583-53-9 1,2-Dibromobenzene CAS#:103-82-2 Phenylacetic acid

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Binding of bis-(2-ethylhexyl) phthalate at the surface of hydrozincite nanocrystals: An example of organic molecules absorption onto nanocrystalline minerals.

J. Colloid. Interface Sci. 457 , 298-306, (2015)

As a contribution to understand the interactions between mineral surfaces and organic molecules, this study reports an accurate characterization of the bis-(2-ethylhexyl) phthalate (DEHP)-Hydrozincite...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

Comparative evaluation of five plant extracts and juices for nanoiron synthesis and application for hexavalent chromium reduction.

Sci. Total Environ. 539 , 105-13, (2015)

The effectiveness of five plant extracts and juices, i.e. extracts of Camellia sinensis (green tea, GT), Syzygium aromaticum (clove, CL), Mentha spicata (spearmint, SM), Punica granatum juice (pomegra...

Dihydrogen benzene-1,2-dicarboxylate

Hydrogen phthalate

o-Phthalic acid

Phthalic acid

EINECS 201-873-2

1,2-Benzenedicarboxylate, dihydrogen salt

o-Dicarboxybenzene

1,2-Benzenedicarboxylic acid

ortho-phthalic acid

QVR BVQ

MFCD00002467

1,2-BENZENEDICABOXYLIC ACID

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