Synthesis of 4-maleimidobutyric acid and related maleimides

RM de Figueiredo, P Oczipka, R Fröhlich…

Index: De Figueiredo, Renata Marcia; Oczipka, Philipp; Froehlich, Roland; Christmann, Mathias Synthesis, 2008 , # 8 p. 1316 - 1318

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Citation Number: 13

Abstract

Abstract Maleimidoalkanoic acids and their activated derivatives, such as their N- hydroxysuccinimide esters, are important, though expensive, linkers for the conjugation of biomolecules. During our synthesis of UCS1025A, we have developed a chromatography- free preparation of 4-maleimidobutyric acid on a one-mole scale.