5-Maleimidovaleric acid

Modify Date: 2024-01-12 15:48:38

5-Maleimidovaleric acid structure	Common Name	5-Maleimidovaleric acid
	CAS Number	57078-99-6	Molecular Weight	197.188
	Density	1.3±0.1 g/cm3	Boiling Point	400.7±28.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	196.2±24.0 °C

Use of 5-Maleimidovaleric acid

5-Maleimidovaleric acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid
Synonym	More Synonyms

Description	5-Maleimidovaleric acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Hazard Codes	Xi
HS Code	2925190090

Maleic anhydride

CAS#:108-31-6

5-Aminovaleric acid

CAS#:660-88-8

~60%

5-Maleimidovale...

CAS#:57078-99-6

Literature: De Figueiredo, Renata Marcia; Oczipka, Philipp; Froehlich, Roland; Christmann, Mathias Synthesis, 2008 , # 8 p. 1316 - 1318

Precursor 2
CAS#:108-31-6 Maleic anhydride CAS#:660-88-8 5-Aminovaleric acid
DownStream 0

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%