Convenient synthesis and biological profile of 5-amino-substituted 1, 2, 4-oxadiazole derivatives

…, AE Koumbis, KE Litinas, D Hadjipavlou-Litina…

Index: Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645

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Citation Number: 32

Abstract

We describe herein a convenient straightforward synthesis of 5-amino-substituted 1, 2, 4- oxadiazoles, upon the reactions of amidoximes with carbodiimides, as well as their further derivatization to acetamides, in good yields. Most of the compounds exhibited in general low interaction with the stable radical 1, 1-diphenyl-2-picryl-hydrazyl. Compounds 32 and 39 inhibited significantly soybean lipoxygenase. Selected compounds were screened for ...

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