1,3-Dicyclohexylurea

Modify Date: 2024-01-01 20:18:51

1,3-Dicyclohexylurea Structure
1,3-Dicyclohexylurea structure
Common Name 1,3-Dicyclohexylurea
CAS Number 2387-23-7 Molecular Weight 224.34
Density 1.2±0.1 g/cm3 Boiling Point 364.3±25.0 °C at 760 mmHg
Molecular Formula C13H24N2O Melting Point 232-233 °C(lit.)
MSDS Chinese USA Flash Point 174.1±23.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 1,3-Dicyclohexylurea


1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats[1].

 Names

Name 1,3-dicyclohexylurea
Synonym More Synonyms

 1,3-Dicyclohexylurea Biological Activity

Description 1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats[1].
Related Catalog
In Vivo 1,3-Dicyclohexylurea (Sprague Dawley rats, 30 mg/kg, Orally, once) shows antihypertensive efficacy when milled to reduce particle size, thus improving dissolution and oral bioavailability[1].
References

[1]. Ghosh S, et al. Oral delivery of 1,3-dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive rats. Basic Clin Pharmacol Toxicol. 2008 May;102(5):453-8.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 364.3±25.0 °C at 760 mmHg
Melting Point 232-233 °C(lit.)
Molecular Formula C13H24N2O
Molecular Weight 224.34
Flash Point 174.1±23.2 °C
Exact Mass 224.188858
PSA 41.13000
LogP 3.85
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.586

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;N: Dangerous for the environment;
Risk Phrases 22-51/53
Safety Phrases S61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
HS Code 2924299090

 Synthetic Route

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

F0902-7614
MFCD00003829
Methanol, 1-(cyclohexylamino)-1-(cyclohexylimino)-, (E)-
EINECS 219-213-7
N,N'-Dicyclohexylurea
1,3-Dicyclohexylurea
N,N-Dicyclohexylurea
Urea, N,N'-dicyclohexyl-
Urea,3-dicyclohexyl
dicyclohexyl urea
N,N‘-Dicyclohexylurea
1,3-dicyclohexyl-urea
N,N'-Dicyclohexylcarbamimidic acid
DCW
N,N′-Dicyclohexylurea
Urea,N'-dicyclohexyl
1,3-dicyclohexylcarbodiimide
Urea,N,N'-dicyclohexyl
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