α-Chymotrypsin-catalysed peptide synthesis via the kinetically controlled approach using activated esters as acyl donors in organic solvents with low water content: …

…, M Nishikawa, K Hamahara, K Imagawa…

Index: Miyazawa, Toshifumi; Nakajo, Shin'ichi; Nishikawa, Miyako; Hamahara, Kazumi; Imagawa, Kiwamu; Ensatsu, Eiichi; Yanagihara, Ryoji; Yamada, Takashi Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 1 p. 82 - 86

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Citation Number: 28

Abstract

The coupling efficiency in the α-chymotrypsin-catalysed peptide synthesis via the kinetically controlled approach is greatly improved by the use of activated esters such as the 2, 2, 2- trifluoroethyl ester as acyl donors instead of the conventional methyl ester in organic solvents such as acetonitrile with low water content. This approach is useful for the incorporation of non-protein amino acids such as halogenophenylalanines into peptides.

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