Chemical Communications

Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate …

RG Bhat, S Sinha, S Chandrasekaran

Index: Bhat, Ramakrishna G.; Sinha, Surajit; Chandrasekaran, Srinivasan Chemical Communications, 2002 , # 8 p. 812 - 813

Full Text: HTML

Citation Number: 16

Abstract

However, in recent years the use of Fmoc amino acid chlorides, 3 Fmoc amino acid fluorides 4 and N-Bts protected amino acid chlorides 5 have found use in the racemisation-free synthesis of peptides in high yield. The limitation of these methods is the use of basic or harsher acidic conditions that are used for the N-deprotection which leads to undesired by-products. ... Herein we report the use of a propargyloxycarbonyl (Poc) group as a novel N-protecting group, ...

Related Articles:

3-Triphenylphosphonio-2, 5-piperazinediones as new chiral glycine cation equivalents

[Tetrahedron Asymmetry, , vol. 22, # 8 p. 823 - 833]

3-Triphenylphosphonio-2, 5-piperazinediones as new chiral glycine cation equivalents

[Gorewoda, Tadeusz; Mazurkiewicz, Roman; Simka, Wojciech; Mloston, Grzegorz; Schroeder, Grzegorz; Kubicki, MacIej; Kuznik, Nikodem Tetrahedron Asymmetry, 2011 , vol. 22, # 8 p. 823 - 833]

A mild Boc deprotection and the importance of a free carboxylate

[Thaqi, Ali; McCluskey, Adam; Scott, Janet L. Tetrahedron Letters, 2008 , vol. 49, # 49 p. 6962 - 6964]

Facile removal strategy for allyl and allyloxycarbonyl protecting groups using solid-supported barbituric acid under palladium catalysis

[Tsukamoto, Hirokazu; Suzuki, Takamichi; Kondo, Yoshinori Synlett, 2003 , # 8 p. 1105 - 1108]

Deracemisation and stereoinversion of α-amino acids using D-amino acid oxidase and hydride reducing agents

[Beard, Timothy M; Turner, Nicholas J Chemical communications (Cambridge, England), 2002 , # 3 p. 246 - 247]

More Articles...